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They do make professional ozone machine. We use to work them at work to neutralize the smell in offices where the previous occupant smoked. Shut the door, let it run for 3 days. Air it out and vacuum and 99% of the smell is gone. Just don't go into the room until the ozone clears.
Same as car, ozium spray. Works. Not that I smoke Indoors, but in the few extremley rare instances over the past decade, it works. Spray in vents as this is where smoke travels.
There was a day, before kids, where my wife didn't mind me smoking cigars in my study but those days are long gone. Now, the closest I can get is the garage. However, when I did smoke inside, I would use Ozium religiously. That stuff is amazing. The problem though is trying to find it in the larger 14.5 oz size. Years ago it was easy but they must have discontinued making it in that size for some reason. I've looked everywhere for it and only find the 1.5 or .08 oz sizes. Those are fine for occasional uses, but if you need to use them very much, that will get pretty expensive. Nonetheless, the stuff does work quite well.